{
  "_id": "6acf4564d9de2f3f33fc9df3",
  "Package": "SlideCNA",
  "Title": "Calls Copy Number Alterations from Slide-Seq Data",
  "Version": "0.1.0",
  "Authors@R": "c(person(given = \"Diane\",\nfamily = \"Zhang\",\nrole = c(\"aut\", \"cre\"),\nemail = \"dkzhang711@gmail.com\",\ncomment = c(ORCID = \"0000-0002-0268-4413\")),\nperson(given = \"Johanna\",\nfamily = \"Klughammer\",\nrole = c(\"aut\"),\nemail = \"klughammer@genzentrum.lmu.de\",\ncomment = c(ORCID = \"0000-0002-3628-9278\")),\nperson(given = \"Jan\",\nfamily = \"Watter\",\nrole = c(\"aut\"),\nemail = \"jan.watter@gmail.com\",\ncomment = c(ORCID = \"0000-0001-7519-731X\")),\nperson(\"Broad Institute of MIT and Harvard\", role = c(\"cph\", \"fnd\")))",
  "Description": "This takes spatial single-cell-type RNA-seq data\n(specifically designed for Slide-seq v2) that calls copy number\nalterations (CNAs) using pseudo-spatial binning, clusters\ncellular units (e.g. beads) based on CNA profile, and\nvisualizes spatial CNA patterns. Documentation about 'SlideCNA'\nis included in the the pre-print by Zhang et al. (2022,\n<doi:10.1101/2022.11.25.517982>). The package 'enrichR' (>=\n3.0), conditionally used to annotate SlideCNA-determined\nclusters with gene ontology terms, can be installed at\n<https://github.com/wjawaid/enrichR> or with\ninstall_github(\"wjawaid/enrichR\").",
  "License": "GPL (>= 3)",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.3.2",
  "Config/testthat/edition": "3",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-10-14 08:11:47 UTC",
    "User": "root"
  },
  "Author": "Diane Zhang [aut, cre]\n(<https://orcid.org/0000-0002-0268-4413>), Johanna Klughammer\n[aut] (<https://orcid.org/0000-0002-3628-9278>), Jan Watter\n[aut] (<https://orcid.org/0000-0001-7519-731X>), Broad\nInstitute of MIT and Harvard [cph, fnd]",
  "Maintainer": "Diane Zhang <dkzhang711@gmail.com>",
  "Config/pak/sysreqs": "cmake libfreetype6-dev libglpk-dev make libicu-dev\nlibpng-dev libuv1-dev libxml2-dev libssl-dev python3 zlib1g-dev",
  "Repository": "https://dzhang777.r-universe.dev",
  "Date/Publication": "2025-01-23 17:40:05 UTC",
  "RemoteUrl": "https://github.com/cran/SlideCNA",
  "RemoteRef": "HEAD",
  "RemoteSha": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
  "_user": "dzhang777",
  "_type": "src",
  "_file": "SlideCNA_0.1.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/0e1e072aedfef56718b1913be4c007daf8df11a14f16124985f455f3985d71b7",
  "_filesize": 168551,
  "_sha256": "0e1e072aedfef56718b1913be4c007daf8df11a14f16124985f455f3985d71b7",
  "_expires": "2027-01-22T09:03:30.000Z",
  "_created": "2026-10-14T08:11:47.000Z",
  "_published": "2026-10-14T09:03:32.394Z",
  "_buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_jobs": [
    {
      "job": 115750549111,
      "time": 166,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11879760652"
    },
    {
      "job": 115750548725,
      "time": 156,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11879595785"
    },
    {
      "job": 115750548650,
      "time": 194,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11881671554"
    },
    {
      "job": 115750548850,
      "time": 174,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11881616560"
    },
    {
      "job": 115748802723,
      "time": 280,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11878738538"
    },
    {
      "job": 115750548611,
      "time": 155,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "11879840414"
    },
    {
      "job": 115750548828,
      "time": 89,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11878961609"
    },
    {
      "job": 115750548869,
      "time": 124,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11879205912"
    },
    {
      "job": 115750548790,
      "time": 128,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11879605915"
    }
  ],
  "_upstream": "https://github.com/cran/SlideCNA",
  "_commit": {
    "id": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
    "author": "Diane Zhang <dkzhang711@gmail.com>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 0.1.0\n",
    "time": 1737654005
  },
  "_maintainer": {
    "name": "Diane Zhang",
    "email": "dkzhang711@gmail.com",
    "login": "dzhang777",
    "description": "",
    "uuid": 56312693,
    "orcid": "0000-0002-0268-4413"
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "data.table",
      "role": "Imports"
    },
    {
      "package": "reshape2",
      "role": "Imports"
    },
    {
      "package": "dplyr",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "scales",
      "role": "Imports"
    },
    {
      "package": "pheatmap",
      "role": "Imports"
    },
    {
      "package": "cluster",
      "role": "Imports"
    },
    {
      "package": "factoextra",
      "role": "Imports"
    },
    {
      "package": "dendextend",
      "role": "Imports"
    },
    {
      "package": "Seurat",
      "role": "Imports"
    },
    {
      "package": "tidyselect",
      "role": "Imports"
    },
    {
      "package": "stringr",
      "role": "Imports"
    },
    {
      "package": "magrittr",
      "role": "Imports"
    },
    {
      "package": "tibble",
      "role": "Imports"
    },
    {
      "package": "futile.logger",
      "role": "Imports"
    },
    {
      "package": "mltools",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    },
    {
      "package": "enrichR",
      "version": ">= 3.0",
      "role": "Suggests"
    }
  ],
  "_owner": "cran",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 0,
  "_contributors": [
    {
      "user": "dzhang777",
      "count": 1,
      "uuid": 56312693
    }
  ],
  "_userbio": {
    "uuid": 56312693,
    "type": "user",
    "name": "dzhang777",
    "followers": 0
  },
  "_downloads": {
    "count": 252,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/SlideCNA"
  },
  "_searchresults": 3,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "extra/SlideCNA.html"
  ],
  "_realowner": "dzhang777",
  "_cranurl": false,
  "_releases": [
    {
      "version": "0.1.0",
      "date": "2025-01-23"
    }
  ],
  "_exports": [
    ":=",
    "%>%",
    "bin",
    "bin_metadata",
    "center_rm",
    "clone_so",
    "cnv_heatmap",
    "dat_to_long",
    "find_cluster_markers",
    "find_go_terms",
    "get_num_clust",
    "long_to_bin",
    "make_seurat_annot",
    "make_so_bin",
    "mean_cnv_plot",
    "mode",
    "plot_clones",
    "prep",
    "prep_cnv_dat",
    "quantile_plot",
    "ref_adj",
    "run_enrichr",
    "run_slide_cna",
    "scale_nUMI",
    "scalefit",
    "SpatialPlot",
    "weight_rollmean",
    "weight_rollmean_sub"
  ],
  "_help": [
    {
      "page": "bin",
      "title": "Subfunction of bin_metadata() for expression/positional binning",
      "topics": [
        "bin"
      ]
    },
    {
      "page": "bin_metadata",
      "title": "Spatio-molecular binning of relative expression intensities",
      "topics": [
        "bin_metadata"
      ]
    },
    {
      "page": "center_rm",
      "title": "Center expression intensities",
      "topics": [
        "center_rm"
      ]
    },
    {
      "page": "clone_so",
      "title": "Add clone information to meta data of seurat object and bin the beads",
      "topics": [
        "clone_so"
      ]
    },
    {
      "page": "cnv_heatmap",
      "title": "Plot CNV scores on a heat map",
      "topics": [
        "cnv_heatmap"
      ]
    },
    {
      "page": "dat_to_long",
      "title": "Convert data to long format and add in metadata",
      "topics": [
        "dat_to_long"
      ]
    },
    {
      "page": "find_cluster_markers",
      "title": "Find and plot top n DEGs per cluster",
      "topics": [
        "find_cluster_markers"
      ]
    },
    {
      "page": "find_go_terms",
      "title": "Find and plot top n GO-enriched terms per cluster",
      "topics": [
        "find_go_terms"
      ]
    },
    {
      "page": "get_num_clust",
      "title": "Find optimal number of clusters",
      "topics": [
        "get_num_clust"
      ]
    },
    {
      "page": "long_to_bin",
      "title": "Convert to wide bin x genes + metadata format",
      "topics": [
        "long_to_bin"
      ]
    },
    {
      "page": "make_seurat_annot",
      "title": "Creation of Seurat object",
      "topics": [
        "make_seurat_annot"
      ]
    },
    {
      "page": "make_so_bin",
      "title": "Make a binned version of a Seurat object",
      "topics": [
        "make_so_bin"
      ]
    },
    {
      "page": "mean_cnv_plot",
      "title": "Plot mean CNV scores per bin and per chromosome",
      "topics": [
        "mean_cnv_plot"
      ]
    },
    {
      "page": "mode",
      "title": "Subfunction of long_to_bin() that finds mode of vector/column",
      "topics": [
        "mode"
      ]
    },
    {
      "page": "plot_clones",
      "title": "Plot cluster/clone information",
      "topics": [
        "plot_clones"
      ]
    },
    {
      "page": "prep",
      "title": "Infercnv-based preparation of relative gene expression intensities",
      "topics": [
        "prep"
      ]
    },
    {
      "page": "prep_cnv_dat",
      "title": "Prepare data for CNV heat map",
      "topics": [
        "prep_cnv_dat"
      ]
    },
    {
      "page": "quantile_plot",
      "title": "Plot CNV score quantiles per bin and per chromosome",
      "topics": [
        "quantile_plot"
      ]
    },
    {
      "page": "ref_adj",
      "title": "Adjust for Reference (Normal) Beads",
      "topics": [
        "ref_adj"
      ]
    },
    {
      "page": "run_enrichr",
      "title": "Subfunction to get significantly enriched GO terms given a set of signfiicant beads and genes",
      "topics": [
        "run_enrichr"
      ]
    },
    {
      "page": "run_slide_cna",
      "title": "Run SlideCNA workflow",
      "topics": [
        "run_slide_cna"
      ]
    },
    {
      "page": "scale_nUMI",
      "title": "Scale for nUMI (UMI Count) to generate CNV scores",
      "topics": [
        "scale_nUMI"
      ]
    },
    {
      "page": "scalefit",
      "title": "Subfunction for scale_nUMI that normalizes a given bin for UMI count and centers the mean CNV score at 1",
      "topics": [
        "scalefit"
      ]
    },
    {
      "page": "SpatialPlot",
      "title": "Spatial plots of meta data",
      "topics": [
        "SpatialPlot"
      ]
    },
    {
      "page": "weight_rollmean",
      "title": "Expressional smoothing along a chromosome using a weighted pyramidal moving average",
      "topics": [
        "weight_rollmean"
      ]
    },
    {
      "page": "weight_rollmean_sub",
      "title": "Subfunction of weight_rollmean",
      "topics": [
        "weight_rollmean_sub"
      ]
    }
  ],
  "_readme": "https://github.com/cran/SlideCNA/raw/HEAD/README.md",
  "_rundeps": [
    "abind",
    "askpass",
    "backports",
    "base64enc",
    "BH",
    "bitops",
    "boot",
    "broom",
    "bslib",
    "cachem",
    "car",
    "carData",
    "caTools",
    "cli",
    "cluster",
    "codetools",
    "colorspace",
    "commonmark",
    "corrplot",
    "cowplot",
    "cpp11",
    "crosstalk",
    "curl",
    "data.table",
    "deldir",
    "dendextend",
    "Deriv",
    "digest",
    "doBy",
    "dotCall64",
    "dplyr",
    "dqrng",
    "DT",
    "ellipse",
    "emmeans",
    "estimability",
    "evaluate",
    "factoextra",
    "FactoMineR",
    "farver",
    "fastDummies",
    "fastmap",
    "fitdistrplus",
    "flashClust",
    "FNN",
    "fontawesome",
    "forecast",
    "formatR",
    "Formula",
    "fracdiff",
    "fs",
    "futile.logger",
    "futile.options",
    "future",
    "future.apply",
    "generics",
    "ggplot2",
    "ggpubr",
    "ggrepel",
    "ggridges",
    "ggsci",
    "ggsignif",
    "globals",
    "glue",
    "goftest",
    "gplots",
    "gridExtra",
    "gtable",
    "gtools",
    "here",
    "highr",
    "htmltools",
    "htmlwidgets",
    "httpuv",
    "httr",
    "ica",
    "igraph",
    "irlba",
    "isoband",
    "jquerylib",
    "jsonlite",
    "KernSmooth",
    "knitr",
    "labeling",
    "lambda.r",
    "later",
    "lattice",
    "lazyeval",
    "leaps",
    "lifecycle",
    "listenv",
    "lme4",
    "lmtest",
    "magrittr",
    "MASS",
    "Matrix",
    "MatrixModels",
    "matrixStats",
    "memoise",
    "mgcv",
    "mime",
    "miniUI",
    "minqa",
    "mltools",
    "modelr",
    "multcompView",
    "mvtnorm",
    "nlme",
    "nloptr",
    "nnet",
    "numDeriv",
    "openssl",
    "otel",
    "parallelly",
    "patchwork",
    "pbapply",
    "pbkrtest",
    "pheatmap",
    "pillar",
    "pkgconfig",
    "plotly",
    "plyr",
    "png",
    "polyclip",
    "polynom",
    "progressr",
    "promises",
    "purrr",
    "quantreg",
    "R6",
    "RANN",
    "rappdirs",
    "rbibutils",
    "RColorBrewer",
    "Rcpp",
    "RcppAnnoy",
    "RcppArmadillo",
    "RcppEigen",
    "RcppHNSW",
    "RcppProgress",
    "RcppThread",
    "RcppTOML",
    "Rdpack",
    "reformulas",
    "reshape2",
    "reticulate",
    "rlang",
    "rmarkdown",
    "ROCR",
    "rprojroot",
    "RSpectra",
    "rstatix",
    "Rtsne",
    "S7",
    "sass",
    "scales",
    "scattermore",
    "scatterplot3d",
    "sctransform",
    "Seurat",
    "SeuratObject",
    "shiny",
    "showtext",
    "showtextdb",
    "sitmo",
    "sourcetools",
    "sp",
    "spam",
    "SparseM",
    "spatstat.data",
    "spatstat.explore",
    "spatstat.geom",
    "spatstat.random",
    "spatstat.sparse",
    "spatstat.univar",
    "spatstat.utils",
    "stringi",
    "stringr",
    "survival",
    "sys",
    "sysfonts",
    "tensor",
    "tibble",
    "tidyr",
    "tidyselect",
    "timeDate",
    "tinytex",
    "urca",
    "utf8",
    "uwot",
    "vctrs",
    "viridis",
    "viridisLite",
    "withr",
    "xfun",
    "xtable",
    "yaml",
    "zoo"
  ],
  "_score": 1.6989700043360187,
  "_indexed": true,
  "_nocasepkg": "slidecna",
  "_universes": [
    "dzhang777"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-10-14T08:14:34.000Z",
      "distro": "resolute",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/a791762903a7ffa2ab1e27495db56a4e8d8f1916a12fc5baf560cfb006d95c7b",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-10-14T08:14:21.000Z",
      "distro": "resolute",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/ab806cf19c2e11a039b2efcfd6a02722ca3f807bec6a1f3c98d355b231b52815",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-10-14T08:57:43.000Z",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/b56fb17d2b154a7515a36b2c479a27a3a337fa7fb5171ed53af28f70c2089571",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-10-14T09:02:14.000Z",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/fcba114f8406a6728309897cac3ef503dc7a956fa25ae6d2b2d6f8e5fd4e266c",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.1.0",
      "date": "2026-10-14T08:14:42.000Z",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/5eae28106ed829f50121b5e68157c1941cdacde6d74acb8868949718eb8378cb",
      "status": "success",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-14T08:13:15.000Z",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/719f9ba9672a9eede8f228853ca223c4a03459f56dbc1c9f5f75b14b9280b4e6",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-14T08:13:39.000Z",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/03896bc5fa0542e5e81d1b8e40d952b130bba10123b7d9891836ddc545be2bd9",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-14T08:13:45.000Z",
      "commit": "fdea2a492e8474f60b4dd58168977ca7fba5021a",
      "fileid": "https://r2.ropensci.org/339910d6e1ada099a55bad2d8d2aa563b475bcf102ae1183e07eaf269baa01b8",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/dzhang777/actions/runs/38532872438"
    }
  ]
}